By T.K. Ghose ,A. Fiechter, N.Blakebrough
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Additional resources for Advances in Biochemical Engineering, Volume 008: Mass Transfer in Biotechnology
As observed previously, the turbine does not satisfy these conditions. However, this is not to say that the incompatibility is so great as to make useless the overall approach. However, further work is required to define the range of applicability. Finally, it is interesting to note that Roels et a/. [ 18 ] report that with only minor modification their model can be used to correlate the A. niger yield stress data of Solomons and Weston  and that in particular ~'y a X 2"s, (38) where X is the mycelial concentration.
Furthermore, the response of the system to the control action will not be uniform; response will be more rapid in V~than in Vj. Finally, sensor response per se will also depend on sensor location; diffusional resistance will be greater in V2 than in V1and therefore sensor response will be slower in Vj. One need only imagine the situation of a pH probe located in V2and reading a pH a few tenths of a unit different than the pH in II1 to realize the potential for the creation of environmental extremes which might not be tolerated by the productive population in V~.
Deindoerfer and West  report that S. griseus broths exhibit Bingham plastic behavior early in the batch (24 h) but Newtonian behavior later ( 4 8 - 9 6 h); the Newtonian viscosity increases with time but never becomes as great as the original r/p. The effects of initial medium composition were not reported. Given what was probably a very low shear rate (previously discussed in connection with the work of these authors on P. chrysogenum) it is possible that the Newtonian viscosity reported was actually the zero-shear viscosity of the suspension.
Advances in Biochemical Engineering, Volume 008: Mass Transfer in Biotechnology by T.K. Ghose ,A. Fiechter, N.Blakebrough