By Pooria Pasbakhsh; A K Haghi; G E Zaikov

ISBN-10: 1482254174

ISBN-13: 9781482254174

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2) [40–41]. It also indicates that lipase can partially penetrate into pores of PHB film but the enzymatic degradation proceeds mainly on the surface of the coarse polymer film achievable for lipase. Two additional effects reported for depolymerases could be of importance. It was concluded that segmental mobility in amorphous phase and polymer hydrophobicity play an important role in enzymatic PHB degradation by nonspecific esterases [14]. Significant impairment of the tensile strength and other mechanical properties were observed during enzymatic biodegradation of PHB threads in serum and blood.

The spheres were surrounded by one or two layers of spindle cells, and infiltration of inflammatory cells and mononuclear cells into these layers was recognized at 1 week after implantation. After 4 weeks, the number of inflammatory cells had decreased and the layers of spindle cells had thickened. No inflammatory cells were seen at 8 weeks, and the spheres were encapsulated by spindle cells. The toxicity of PHB microspheres was evaluated by weight change and survival times in L1210 tumor-bearing mice.

The long absorption time produced a foreign body reaction, which was restricted to macrophages forming a peripolymer layer [23, 65, 68, 72]. Very important data that clarifies the tissue response that contributes to biodegradation of PHB was obtained by Lobler. A significant increase of expression of two specific lipases after 7 and 14 days of PHB contact with animal tissues was demonstrated. Moreover, liver-specific genes were induced with similar results. It is striking that pancreatic enzymes are induced in the gastric wall after contact with biomaterials [46].

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Applied research on polymer composites by Pooria Pasbakhsh; A K Haghi; G E Zaikov

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